THE INTERPLAY BETWEEN GUT MICROBIOTA, IMMUNE TOLERANCE, AND REGULATORY T-CELLS IN ALLERGIC DISEASES

Abstract

Allergic diseases, including atopic dermatitis, allergic rhinitis, food allergy, and bronchial asthma, are characterized by inappropriate immune responses to otherwise harmless environmental antigens. The development of these conditions involves genetic predisposition, environmental exposures, epithelial barrier dysfunction, and alterations in immune regulation. Increasing evidence suggests that the gut microbiota contributes to immune system maturation and the establishment of immune tolerance, particularly during early childhood